Department of Defense
INSTRUCTION
NUMBER 5210.88
January 19, 2016
Incorporating Change 1, October 6, 2017
USD(AT&L)
SUBJECT: Security Standards for Safeguarding Biological Select Agents and Toxins (BSAT)
References: See Enclosure 1
1. PURPOSE. This instruction:
a. Reissues DoD Directive (DoDD) 5210.88 (Reference (a)) as an instruction in accordance
with the authority in DoDD 5134.01 (Reference (b)), Deputy Secretary of Defense Memorandum
(Reference (c)), Deputy Secretary of Defense Memorandum (Reference (d)), Deputy Secretary of
Defense Memorandum (Reference (e)) and paragraph E1.3 of DoD Instruction (DoDI) 5200.08
(Reference (e)(f)) to establish policy, assign responsibilities, and provide procedures for:
(1) The execution of the DoD BSAT Security Program.
(2) Physical security and information security for BSAT in the possession of the DoD,
and personnel reliability for Tier 1 BSAT as defined by part 73 of Title 42, Code of Federal
Regulations (CFR) (Reference (f)(g)), part 331 of Title 7, CFR (Reference (g)(h)), and part 121
of Title 9, CFR (Reference (h)(i)), collectively referred to in this instruction as the Select Agent
Regulations (SAR).
b. Revises DoD BSAT security policy to:
(1) Conform with Executive Order 13546 (Reference (i)(j)).
(2) Implement the SAR.
(3) Implement sections 201-231 of Public Law 107-188 (Reference (j)(k)).
c. Incorporates and cancels DoDI 5210.89 (Reference (k)(l)).
2. APPLICABILITY. This instruction:
a. Applies to:
